Pancreatitis promotes oncogenic KrasG12D-induced pancreatic transformation through activation of Nupr1
نویسندگان
چکیده
During the initiation stage of pancreatic adenocarcinoma induced by oncogenic Kras, pancreatic cells are exposed to both a protumoral effect and an opposing tumor suppressive process known as oncogene-induced senescence. Pancreatitis disrupts this balance in favor of the transforming effect of oncogenes by lowering the tumor suppressive threshold of oncogene-induced senescence through expression of the stress protein Nupr1.
منابع مشابه
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عنوان ژورنال:
دوره 1 شماره
صفحات -
تاریخ انتشار 2014